Changes in Breast Density and Circulating Estrogens in Postmenopausal Women Receiving Adjuvant Anastrozole
نویسندگان
چکیده
منابع مشابه
Changes in breast density and circulating estrogens in postmenopausal women receiving adjuvant anastrozole.
Factors associated with an increased risk of breast cancer include prior breast cancer, high circulating estrogens, and increased breast density. Adjuvant aromatase inhibitors are associated with a reduction in incidence of contralateral breast cancer. We conducted a prospective, single-arm, single-institution study to determine whether use of anastrozole is associated with changes in contralat...
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women with mammary carcinoma, the concentrations of total radioactive estrogen and the individual radiometabolites estradiol and estrone, and an uncharacterized fraction (Ep), were determined in several body tissues. Specimens of mammary tissue, mammary tumor, abdominal fat, muscle, and skin were removed 30 minutes after the infusion of the radioactive hormone. The median concentration of radio...
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For more than 20 years, tamoxifen has been the gold standard for the adjuvant treatment of postmenopausal women with hormone-responsive early breast cancer. However, recent randomized trials have shown efficacy and tolerability benefits with the third-generation aromatase inhibitor anastrozole, resulting in an increased use of this agent in the adjuvant setting. Data on anastrozole's long-term ...
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PURPOSE To assess the predictive value of Ki67 expression in postmenopausal hormone receptor-positive early-breast cancer patients, who were either treated with adjuvant tamoxifen (TAM) alone or with TAM followed by anastrozole (ANA). EXPERIMENTAL DESIGN Expression of Ki67 was determined centrally by immunohistochemistry on whole tissue sections of postmenopausal endocrine-responsive breast c...
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ژورنال
عنوان ژورنال: Cancer Prevention Research
سال: 2011
ISSN: 1940-6207,1940-6215
DOI: 10.1158/1940-6207.capr-11-0154